Cardiolipin biosynthesis in the isolated heart
نویسندگان
چکیده
منابع مشابه
Cardiolipin biosynthesis in the isolated heart.
The pathway for the biosynthesis of new cardiolipin was investigated in the isolated perfused intact rat heart. Isolated rat hearts were perfused in the Langendorff mode for up to 60 min with Krebs-Henseleit buffer containing 0.1 microM [U-14C]glycerol. Analysis of radioactivity incorporated into phospholipids in the organic phase revealed an increase in radioactivity incorporated into phosphat...
متن کاملDysregulation of cardiolipin biosynthesis in pediatric heart failure.
Cardiolipin, a unique phospholipid in the inner mitochondrial membrane, is critical for optimal mitochondrial function. CL abnormalities have been demonstrated in the failing rodent and adult human heart. The aim of this study was to determine whether abnormalities in CL content and the CL biosynthesis and remodeling pathways are present in pediatric idiopathic dilated cardiomyopathy (IDC). A c...
متن کاملRole of Phospholipases in Regulation of Cardiolipin Biosynthesis and Remodeling in the Heart and Mammalian Cells
P.S. Tappia and N.S. Dhalla (eds.), Phospholipases in Health and Disease, Advances in Biochemistry in Health and Disease 10, DOI 10.1007/978-1-4939-0464-8_2, © Springer Science+Business Media New York 2014 Abstract Cardiolipin is a key mitochondrial membrane phospholipid involved in the regulation of generation of ATP. Cardiolipin synthesis and remodeling are tightly regulated processes in euka...
متن کاملBiosynthesis of Cardiolipin in Plant Mitochondria.
The properties of cardiolipin synthase were investigated in mitochondria and submitochondrial fractions from etiolated mung bean (Vigna radiata L.) seedlings. Direct evidence is presented that the enzyme utilizes CDP-diacylglycerol in addition to phosphatidylglycerol for the synthesis of cardiolipin. Cardiolipin synthase had an alkaline pH optimum of about 9 and required divalent cations for ac...
متن کاملCardiolipin biosynthesis and remodeling enzymes are altered during development of heart failure.
Cardiolipin (CL) is responsible for modulation of activities of various enzymes involved in oxidative phosphorylation. Although energy production decreases in heart failure (HF), regulation of cardiolipin during HF development is unknown. Enzymes involved in cardiac cardiolipin synthesis and remodeling were studied in spontaneously hypertensive HF (SHHF) rats, explanted hearts from human HF pat...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1994
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2970201